Immunoglobulin (Ig) antigen receptors are composed of a non-covalently- ssociated complex of Ig and two other proteins, Igα and Igβ, which have been designated in the Fifth International Leukocyte Workshop as CD79a and CD79b respectively. CB3-1 reacts with CD79b, which is expressed on surface Ig(sIg)-positive lymphocytes and B-cell lines but only in the cytoplasm of sIg-negative cells including most terminal deoxynucleotidyl transferase (TdT) positive early pre-B and all cytoplasmic μ positive pre-B cell lines. Antibodies to CD79b are helpful in delineating signal transduction pathways activated via antibody receptors during different stages of B-cell differentiation. Profile of peripheral blood lymphocytes analyzed by flow cytometry
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