Reacts with a 66 kDa single chain transmembrane glycoprotein. 2B4 belong to the immunoglobulin superfamily of proteins and is structurally related to CD2-like molecules. It was originally identified in the mouse as a non-MHC-restricted cytotoxicity mediator present on NK cells and CD8+ T cells. In humans, 2B4 is expressed on NK cells, CD8+ T cells, monocytes and basophils, suggesting a broader role for 2B4 in leukocyte activation and possibly a role of immunomodulation in other receptor-ligand interactions to enhance leukocyte activation. 2B4 has been clustered as CD244 in the VIIth HLDA workshop. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of CD244 (2-69) reactivity on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store undiluted at 4°C.
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Nakajima, Cella, Langen, Friedlein, Colonna: "Activating interactions in human NK cell recognition: the role of 2B4-CD48." in: European journal of immunology, Vol. 29, Issue 5, pp. 1676-83, (1999) (PubMed).
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