CD22 antibody
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- Target See all CD22 Antibodies
- CD22 (CD22 Molecule (CD22))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD22 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Brand
- BD Pharmingen™
- Characteristics
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Reacts with the 130-140 kDa glycosylated type I integral membrane protein present on the surface of mature B cells. CD22 is expressed in the cytoplasm of virtually all B cells except plasma cells. CD45RO antigen on T cells and CD75 antigen on B cells have been identified as ligands for CD22. CD22 has been reported to participate in B-cell activation and also as an adhesion molecule. Although the immunobiology of this antigen has not been fully elucidated, reports indicate that ligation of CD22 induces constitutive internalization of the molecule followed by complete degradation. Profile of peripheral blood lymphocytes analyzed on a BD FACScan™ .
BD Pharmingen™ Purified Mouse Anti-Human CD22 - Purified - Clone HIB22 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Clone
- HIB22
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CD22 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store undiluted at 4°C.
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Constitutive endocytosis and degradation of CD22 by human B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 9, pp. 4466-75, (1995) (PubMed).
: "CD22, a B cell-specific receptor, mediates adhesion and signal transduction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 150, Issue 11, pp. 4715-8, (1993) (PubMed).
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Constitutive endocytosis and degradation of CD22 by human B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 9, pp. 4466-75, (1995) (PubMed).
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- Target
- CD22 (CD22 Molecule (CD22))
- Alternative Name
- CD22 (CD22 Products)
- Synonyms
- A530093D23 antibody, Lyb-8 antibody, Lyb8 antibody, SIGLEC-2 antibody, SIGLEC2 antibody, siglec-2 antibody, CD22 antigen antibody, CD22 molecule antibody, Cd22 antibody, CD22 antibody
- Background
- Synonyms: BL-CAM
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