(11 references)-
- Target See all CD15s products
- CD15s
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- Un-conjugated
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Application
- Flow Cytometry (FACS)
- Brand
- BD Pharmingen™
- Characteristics
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Anti-Sialyl-Le[x] monoclonal antibody (clone CSLEX1) is specific for the α2-3 sialosylated form of lacto-N-fucopentaose III, sialyl Lex (Sle[x]). Sle[x] is expressed on granulocytes, monocytes and both normal and tumor cells of diverse origin. It has been shown to be a ligand for both endothelial leukocyte adhesion molecule-1 (ELAM-1 or E-selectin), and granule membrane protein-140 (GMP-140 or P-selectin).
BD Pharmingen™ Purified Mouse Anti-Human CD15s - Purified - Clone CSLEX1 - Isotype Mouse IgM, κ - Reactivity Hu - 0.1 mg - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Clone
- CSLEX1
- Isotype
- IgM kappa
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store undiluted at 4°C.
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: "CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 14, pp. 6224-8, (1991) (PubMed).
: "The selectin GMP-140 binds to sialylated, fucosylated lactosaminoglycans on both myeloid and nonmyeloid cells." in: The Journal of cell biology, Vol. 115, Issue 2, pp. 557-64, (1991) (PubMed).
: "ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex." in: Science (New York, N.Y.), Vol. 250, Issue 4984, pp. 1130-2, (1991) (PubMed).
: "The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140." in: Cell, Vol. 66, Issue 5, pp. 921-33, (1991) (PubMed).
: "Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells." in: Science (New York, N.Y.), Vol. 250, Issue 4984, pp. 1132-5, (1991) (PubMed).
: "Requirement for sialic acid on neutrophils in a GMP-140 (PADGEM) mediated adhesive interaction with activated platelets." in: Biochemical and biophysical research communications, Vol. 172, Issue 3, pp. 1349-56, (1990) (PubMed).
: "An inducible endothelial cell surface glycoprotein mediates melanoma adhesion." in: Science (New York, N.Y.), Vol. 246, Issue 4935, pp. 1303-6, (1990) (PubMed).
: "The cellular basis of site-specific tumor metastasis." in: The New England journal of medicine, Vol. 322, Issue 9, pp. 605-12, (1990) (PubMed).
: "Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 5, pp. 1673-7, (1990) (PubMed).
: "Interleukin 1 promotes tumor cell adhesion to cultured human endothelial cells." in: The Journal of clinical investigation, Vol. 82, Issue 4, pp. 1466-70, (1988) (PubMed).
: "Characterization of sialosylated Lewisx as a new tumor-associated antigen." in: Cancer research, Vol. 44, Issue 11, pp. 5279-85, (1984) (PubMed).
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: "CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 14, pp. 6224-8, (1991) (PubMed).
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- Target
- CD15s
- Abstract
- CD15s Products
- Background
- Synonyms: Sialyl Lewis x
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