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Cyclin E1 antibody (AA 307-410)

CCNE1 Reactivity: Human ELISA, FACS Host: Mouse Monoclonal 5F8C5 unconjugated
Catalog No. ABIN2682980
  • Target See all Cyclin E1 (CCNE1) Antibodies
    Cyclin E1 (CCNE1)
    Binding Specificity
    • 27
    • 16
    • 16
    • 13
    • 9
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 307-410
    Reactivity
    • 145
    • 36
    • 33
    • 3
    • 2
    • 2
    • 2
    Human
    Host
    • 121
    • 23
    • 1
    Mouse
    Clonality
    • 115
    • 30
    Monoclonal
    Conjugate
    • 80
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Cyclin E1 antibody is un-conjugated
    Application
    • 98
    • 49
    • 46
    • 42
    • 32
    • 28
    • 20
    • 13
    • 12
    • 8
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Flow Cytometry (FACS)
    Purpose
    CCNE1 Antibody
    Purification
    Purified antibody
    Immunogen
    Purified recombinant fragment of human CCNE1 (AA: 307-410) expressed in E. Coli.
    Clone
    5F8C5
    Isotype
    IgG1
    Top Product
    Discover our top product CCNE1 Primary Antibody
  • Application Notes

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Target
    Cyclin E1 (CCNE1)
    Alternative Name
    CCNE1 (CCNE1 Products)
    Synonyms
    CCNE1 antibody, ccne antibody, cyclinE antibody, CCNE antibody, AW538188 antibody, CycE1 antibody, CYCLE antibody, Ccne antibody, cyce2 antibody, cycE3 antibody, cyce antibody, fa18e07 antibody, wu:fa18e07 antibody, cyclin E1 antibody, cyclin E1 L homeolog antibody, cyclin E1 S homeolog antibody, CCNE1 antibody, ccne1 antibody, Ccne1 antibody, ccne1.L antibody, ccne1.S antibody
    Background

    Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.

    Aliases: CCNE

    Molecular Weight
    47kDa
    Gene ID
    898
    HGNC
    898
    UniProt
    P24864
    Pathways
    Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Mitotic G1-G1/S Phases
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