HIV-1 Tat antibody (Biotin)

Catalog No. ABIN2669357

Product Details anti-HIV-1 Tat Antibody (Biotin)

Target: HIV-1 Tat

Reactivity: Human Immunodeficiency Virus (HIV)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIV-1 Tat antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: The antibody detects HIV1 tat protein and GST tat fusion protein. HIVI tat protein in sera or plasma and in cell culture supernatant

Characteristics: Tat is a regulatory protein of HIV-1 virus, well conserved among different isolates. Tat is produced early after infection and it's essential for virus replication and infectivity. Tat protein is also immunogenic and antibodies (Ab) against tat have been found to correlate with delayed disease progression and may exert protective effects by inhibiting both HIV-1 replication and the effects of extracellular tat. Moreover, tat is efficiently taken up by monocyte-derived dendritic cells, promotes their maturation and antigen presenting since it enters the major histocompatibility complex class I pathway. Finally, murine vaccination with a biologically active tat protein has been shown to be safe, immunogenic and elicits anti-tat neutralizing Ab and CTL.

Purification: Purified by protein A affinity chromatography and conjugated by NHS-biotin.

Immunogen: Purified recombinant protein HIV-I tat expressed in E. coli

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied in PBS and 0.05 % v/v glycerol

Storage: 4 °C

Target Details for HIV-1 Tat

Target: HIV-1 Tat

Alternative Name: HIV1 Tat (HIV-1 Tat Products)

Target Type: Viral Protein