BCL11B antibody
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- Target See all BCL11B Antibodies
- BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))
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Reactivity
- Human
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Host
- Rat
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Clonality
- Monoclonal
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Conjugate
- This BCL11B antibody is un-conjugated
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Application
- Flow Cytometry (FACS)
- Cross-Reactivity
- Mouse (Murine), Zebrafish
- Cross-Reactivity (Details)
- Mouse, Zebrafish
- Purification
- Protein G affinity purified.
- Clone
- 25B6
- Isotype
- IgG
- Top Product
- Discover our top product BCL11B Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- Hepes-buffered solution, pH 7.5, 0.02 % Sodium azide .
- Storage
- 4 °C
- Storage Comment
- Upon receipt, store undiluted between 2°C and 8°C.
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- Target
- BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))
- Alternative Name
- Bcl11b (BCL11B Products)
- Background
- The transcription factor Bcl11b is expressed in thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies.
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