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BCL11B antibody

BCL11B Reactivity: Human FACS Host: Rat Monoclonal 25B6 unconjugated
Catalog No. ABIN2666299
  • Target See all BCL11B Antibodies
    BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))
    Reactivity
    • 47
    • 8
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    Human
    Host
    • 46
    • 1
    • 1
    Rat
    Clonality
    • 39
    • 9
    Monoclonal
    Conjugate
    • 26
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This BCL11B antibody is un-conjugated
    Application
    • 28
    • 15
    • 11
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Cross-Reactivity
    Mouse (Murine), Zebrafish
    Cross-Reactivity (Details)
    Mouse, Zebrafish
    Purification
    Protein G affinity purified.
    Clone
    25B6
    Isotype
    IgG
    Top Product
    Discover our top product BCL11B Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Hepes-buffered solution, pH 7.5, 0.02 % Sodium azide .
    Storage
    4 °C
    Storage Comment
    Upon receipt, store undiluted between 2°C and 8°C.
  • Target
    BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))
    Alternative Name
    Bcl11b (BCL11B Products)
    Synonyms
    BCL11B antibody, 9130430L19Rik antibody, AI604821 antibody, B630002E05Rik antibody, BCL-11B antibody, Ctip2 antibody, Rit1 antibody, ATL1 antibody, ATL1-alpha antibody, ATL1-beta antibody, ATL1-delta antibody, ATL1-gamma antibody, CTIP-2 antibody, CTIP2 antibody, RIT1 antibody, ZNF856B antibody, hRIT1-alpha antibody, B-cell CLL/lymphoma 11B antibody, B cell leukemia/lymphoma 11B antibody, B-cell CLL/lymphoma 11B (zinc finger protein) antibody, BCL11B antibody, Bcl11b antibody
    Background
    The transcription factor Bcl11b is expressed in thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies.
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