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TIGIT antibody

TIGIT Reactivity: Mouse ICFC Host: Mouse Monoclonal 1G9 unconjugated
Catalog No. ABIN2665413
  • Target See all TIGIT Antibodies
    TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
    Reactivity
    • 24
    • 11
    • 1
    Mouse
    Host
    • 19
    • 14
    • 1
    • 1
    Mouse
    Clonality
    • 18
    • 15
    • 2
    Monoclonal
    Conjugate
    • 23
    • 4
    • 4
    • 2
    • 1
    • 1
    This TIGIT antibody is un-conjugated
    Application
    • 16
    • 15
    • 13
    • 10
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Intracellular Flow Cytometry (ICFC)
    Purification
    The antibody was purified by affinity chromatography.
    Clone
    1G9
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product TIGIT Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
    Alternative Name
    TIGIT (TIGIT Products)
    Synonyms
    VSIG9 antibody, VSTM3 antibody, WUCAM antibody, ENSMUSG00000071552 antibody, Vstm3 antibody, RGD1563191 antibody, T-cell immunoreceptor with Ig and ITIM domains antibody, T cell immunoreceptor with Ig and ITIM domains antibody, TIGIT antibody, Tigit antibody
    Background
    T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as V-set and transmembrane domain-containing protein 3 (Vstm3), is a 26 kD, type I transmembrane protein and member of the CD28 family. TIGIT is expressed on activated T cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. Its ligands are PVR, PVRL2, PVRL3, CD155, and CD112. TIGIT is a negative regulator of NK and T cell activation. Engagement of TIGIT by dendritic cells results in their differentiation into a tolerogenic phenotype, with an increased secretion of IL-10 and a diminished production of IL-12. Mice deficient for TIGIT are more susceptible to autoimmune disease.
    Pathways
    Cancer Immune Checkpoints
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