LAMP5 antibody

Catalog No. ABIN2665219

Product Details anti-LAMP5 Antibody

Target: LAMP5 (Lysosomal-Associated Membrane Protein Family, Member 5 (LAMP5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LAMP5 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: 124-40B

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for LAMP5

Target: LAMP5 (Lysosomal-Associated Membrane Protein Family, Member 5 (LAMP5))

Alternative Name: LAMP5 (LAMP5 Products)

Synonyms: BAD-LAMP antibody, BADLAMP antibody, C20orf103 antibody, LAMP-5 antibody, UNC-43 antibody, 3110035N03Rik antibody, 6330527O06Rik antibody, C13H20orf103 antibody, lamp5 antibody, lysosomal associated membrane protein family member 5 antibody, lysosomal-associated membrane protein family, member 5 antibody, zgc:165600 antibody, LAMP5 antibody, Lamp5 antibody, zgc:165600 antibody

Background: Lysosome-associated membrane protein 5 (LAMP5), also known as BAD-LAMP, UNC-43, and C20orf103, is a new member of LAMP family. It is a transmembrane glycosylated protein localized in the ER-Golgi intermediate compartment (ERGIC). LAMP5 shares sequence and structural homology with the canonical LAMP1 (CD107a) and LAMP2 (CD107b) molecules, harbors an endosomal addressing signal within its cytoplasmic tail, and contains several conserved cysteine residues that allow for the formation of particular structural loops known as LAMP folds. In mice, LAMP5 is expressed in postnatal cortical neurons of particular layers, where it is enriched in defined zones along neuronal projections. Human LAMP5, like its murine homolog, is principally expressed in brain, it is also specifically found in primary CD303 (BDCA-2)-positive pDCs (plasmacytoid dendritic cells). It represents a novel marker of human primary and transformed pDCs.