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- Target See all CD40 Antibodies
- CD40
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD40 antibody is un-conjugated
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Application
- Flow Cytometry (FACS)
- Cross-Reactivity
- Baboon, Chimpanzee, Cynomolgus, Rhesus Monkey, Squirrel Monkey (Saimiri spec.)
- Purification
- The antibody was purified by affinity chromatography.
- Clone
- 5C3
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CD40 Primary Antibody
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anti-CD40 (CD40) (AA 26-187) antibody
CD40 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-CD40 (CD40) antibodyCD40 Reactivity: Human FACS, IHC, IF, StM, DNA Mic Host: Mouse Monoclonal C40-1605 unconjugated
anti-CD40 (CD40) (C-Term) antibodyCD40 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-CD40 (CD40) (AA 21-193) antibodyCD40 Reactivity: Human FACS, WB, ELISA, IHC, ICC, Neut Host: Mouse Monoclonal 4E1B9 unconjugated
anti-CD40 (CD40) (AA 29-107) antibodyCD40 Reactivity: Human FACS, ELISA, IHC, StM, Coat Host: Mouse Monoclonal C40-2383 unconjugated
anti-CD40 (CD40) (AA 1-360) antibodyCD40 Reactivity: Human, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-CD40 (CD40) (Extracellular Domain) antibodyCD40 Reactivity: Human FACS, IHC, St Host: Mouse Monoclonal 5C3 unconjugated
anti-CD40 (CD40) antibody (FITC)CD40 Reactivity: Human FACS Host: Mouse Monoclonal HI40a FITC
anti-CD40 (CD40) antibodyCD40 Reactivity: Human FACS, IHC, IP, Act Host: Rabbit Chimeric G28-5 unconjugated Recombinant Antibody
anti-CD40 (CD40) antibody (FITC)CD40 Reactivity: Human FACS, IF Host: Mouse Monoclonal HI40a FITC
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- CD40
- Alternative Name
- CD40 (CD40 Products)
- Synonyms
- Bp50 antibody, CDW40 antibody, TNFRSF5 antibody, p50 antibody, AI326936 antibody, GP39 antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TRAP antibody, Tnfrsf5 antibody, TNFSF5 antibody, CD40 molecule antibody, CD40 antigen antibody, CD40 antibody, Cd40 antibody
- Background
- CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis.
- Pathways
- NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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