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TNFRSF12A antibody
TNFRSF12A
Reactivity: Human
IHC, FACS, Func
Host: Mouse
Monoclonal
ITEM-1
unconjugated
Product Details anti-TNFRSF12A Antibody
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Target
See all TNFRSF12A Antibodies
TNFRSF12A
(Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
Reactivity
All reactivities for TNFRSF12A antibodies
Human
Host
All hosts for TNFRSF12A antibodies
Mouse
Clonality
All clonalities for TNFRSF12A antibodies
Monoclonal
Conjugate
All conjugates for TNFRSF12A antibodies
This TNFRSF12A antibody is un-conjugated
Application
All applications for TNFRSF12A antibodies
Immunohistochemistry (IHC), Flow Cytometry (FACS), Functional Studies (Func)
Purification
The antibody was purified by affinity chromatography.
Clone
ITEM-1
Isotype
IgG1 kappa
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Discover our top product TNFRSF12A Primary Antibody
Alternatives
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) (AA 104-118) antibody
TNFRSF12A
Reactivity: Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Monkey, Bat, Hamster
WB
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for TNFRSF12A
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Target
TNFRSF12A
(Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
Alternative Name
CD266 (TNFRSF12A Products )
Synonyms
CD266 antibody, FN14 antibody, TWEAKR antibody, AI255180 antibody, C87282 antibody, Fn14 antibody, HPIP antibody, TWEAK-R antibody, TweakR antibody, TNF receptor superfamily member 12A antibody, tumor necrosis factor receptor superfamily, member 12a antibody, TNFRSF12A antibody, Tnfrsf12a antibody
Background
TWEAK receptor is also known as fibroblast growth factor inducible 14 kD protein (Fn14) or CD266. It is a 14 kD transmembrane protein that is expressed on a variety of tissue types. This receptor binds TWEAK and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The TWEAK receptor is rapidly induced during liver regeneration and m play a role in hepatocyte growth. TWEAK receptor engagement can induce cell death and may play a role in inflammation. The ITEM-1 antibody is useful for flow cytometric analysis, induction of tumor cells apoptosis or necrotic cell death, enhancing endothelial cell proliferation, and immunohistochemistry on frozen tissues.
Pathways
Apoptosis , Regulation of Cell Size
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