ZBTB16 antibody (PE)

Catalog No. ABIN2662834

Product Details anti-ZBTB16 Antibody (PE)

Target: ZBTB16 (Zinc Finger and BTB Domain Containing 16 (ZBTB16))

Reactivity: Mouse

Host: Armenian Hamster

Clonality: Monoclonal

Conjugate: This ZBTB16 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Clone: 9E12

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for ZBTB16

Target: ZBTB16 (Zinc Finger and BTB Domain Containing 16 (ZBTB16))

Alternative Name: PLZF (ZBTB16 Products)

Synonyms: PLZF antibody, ZNF145 antibody, ZGC:55675 antibody, AI467657 antibody, Zfp145 antibody, lu antibody, Lx antibody, Plzf antibody, Znf145 antibody, wu:fb93g12 antibody, wu:fc07c10 antibody, zbtb16 antibody, zgc:55675 antibody, zinc finger and BTB domain containing 16 antibody, zinc finger and BTB domain containing 32 antibody, zinc finger and BTB domain containing 16a antibody, ZBTB16 antibody, ZBTB32 antibody, Zbtb16 antibody, zbtb16a antibody

Background: PLZF (promyelocytic leukemia zinc finger), also known as Zbtb16, Zinc finger and BTB domain-containing protein 16, Zfp145, is a member of the BTB-POZ family of transcription factors. It was first identified in a patient with acute promyelocytic leukemia, where a reciprocal chromosomal translocation t(11,17)(q23,q21) resulted in a fusion with RARA gene encoding retinoic acid receptor alpha. Expression of this transcriptional repressor in immune cells differs between human and mouse. In humans, PLZF is expressed in CD34+ progenitor cells and in primitive multipotent hematopoietic cell lines, NK cells, γ/δ T cells, CD4+ and CD8+ T cells. It is also expressed in MR1-specific mucosal-associated invariant T cells as well as in MHC class II-restricted T cells that develop via a thymocyte-thymocyte interaction. PLZF is involved in NK cell function, cellular quiescence, and growth suppression. It also inhibits gene expression induced by retinoic acid receptor. In mice, PLZF is highly expressed in immature CD1d-resricted invariant NKT (iNKT) cells, a subset of γ/δ (Vg1.1+Vd6.3+) T cells, and non-invariant CD1d-restricted T cells. PLZF exists as a homodimer or in complex with PLZP, and has been shown to be involved in the development of NKT cells. It is also reported to be expressed in embryonic tissues, giving rise to hematopoietic progenitors.

Pathways: Positive Regulation of fat Cell Differentiation