SLAMF6 antibody (Pacific Blue)

Catalog No. ABIN2662362

Product Details anti-SLAMF6 Antibody (Pacific Blue)

Target: SLAMF6 (SLAM Family Member 6 (SLAMF6))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This SLAMF6 antibody is conjugated to Pacific Blue

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography, and conjugated with Pacific Blue™ under optimal conditions. The solution is free of unconjugated Pacific Blue™.

Clone: 330-AJ

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for SLAMF6

Target: SLAMF6 (SLAM Family Member 6 (SLAMF6))

Alternative Name: Ly108 (SLAMF6 Products)

Synonyms: SLAMF6 antibody, CD352 antibody, KALI antibody, KALIb antibody, Ly108 antibody, NTB-A antibody, NTBA antibody, SF2000 antibody, KAL1 antibody, KAL1b antibody, RGD1561848 antibody, SLAM family member 6 antibody, SLAMF6 antibody, Slamf6 antibody

Background: Mouse Ly108, also known as SLAMF6 and NTB-A (NK cell, T cell, B cell antigen), is one of the members in The Signaling Lymphocytic Activation Molecule (SLAM) family of immune receptors. It is expressed on T cells, B cells, macrophages, dendritic cells, NK cells, and granulocytes. Homophilic interaction of Ly108 is involved in augmenting cytotoxicity of NK cells. Ly108 has been shown to function on NK cells by augmenting cytotoxicity. It was reported that Ly108 plays an important role in CD4+ T cell responses and innate immunity to bacteria and parasites. In a mouse with a targeted disruption of the Ly108 gene, CD4+ T cells and innate responses are defective. SLAM family of receptors has been implicated in the pathophysiology of autoimmunity. For instance, Ly108 is strongly linked to lupus susceptibility in mice. Ly108 may censor self-reactive B cells as a potential regulator of tolerance checkpoints, safeguarding against autoimmunity. Therefore, Ly108 serves as a regulator of both innate and adaptive immune responses.