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KLRA1 antibody (FITC)
KLRA1
Reactivity: Mouse
FACS
Host: Rat
Monoclonal
YE1-48-10-6
FITC
Product Details anti-KLRA1 Antibody (FITC)
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Target
See all KLRA1 Antibodies
KLRA1
(Killer Cell Lectin-Like Receptor, Subfamily A, Member 1 (KLRA1))
Reactivity
All reactivities for KLRA1 antibodies
Mouse
Host
All hosts for KLRA1 antibodies
Rat
Clonality
All clonalities for KLRA1 antibodies
Monoclonal
Conjugate
All conjugates for KLRA1 antibodies
This KLRA1 antibody is conjugated to FITC
Application
All applications for KLRA1 antibodies
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Clone
YE1-48-10-6
Isotype
IgG2a kappa
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Discover our top product KLRA1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Protect from prolonged exposure to light. Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for KLRA1
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Target
KLRA1
(Killer Cell Lectin-Like Receptor, Subfamily A, Member 1 (KLRA1))
Alternative Name
Ly-49A (KLRA1 Products )
Synonyms
Klra2 antibody, Ly49i8 antibody, A1 antibody, Klra22 antibody, Ly49a antibody, Ly49o<129> antibody, Ly49v antibody, LY49 antibody, KLRA1 antibody, Ly49 antibody, killer cell lectin-like receptor, subfamily A, member 1 antibody, killer cell lectin-like receptor subfamily A, member 1 antibody, Klra1 antibody, KLRA1 antibody, LY49 antibody
Background
Ly-49A is a 44 kD member of the C-type lectin/Ly-49 family proteins. It is a type-II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Ly-49A is present on a subset of NK and NK-T cells. Ly-49A, like other members of this family, inhibits NK cell activation through the recognition and interaction of certain MHC class I haplotypes on potential target cells. The Ly-49A receptor recognizes H-2Dd and H-2Dk, triggering phosphorylation of the ITIM motif in the cytoplasmic domain and recruitment of SHP-1 and SHP-2. The YE1/48.10.6 antibody reacts with NK cells from all mouse strains tested and reverses the inhibition of NK cytotoxicity.
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