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CCL28 antibody (Biotin)

CCL28 Reactivity: Mouse FACS, CyTOF Host: Goat Polyclonal Poly5242 Biotin
Catalog No. ABIN2660745
  • Target See all CCL28 Antibodies
    CCL28 (Chemokine (C-C Motif) Ligand 28 (CCL28))
    Reactivity
    • 20
    • 5
    • 2
    Mouse
    Host
    • 20
    • 2
    Goat
    Clonality
    • 21
    • 1
    Polyclonal
    Conjugate
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CCL28 antibody is conjugated to Biotin
    Application
    • 16
    • 8
    • 5
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Cytometry by Time of Flight (CyTOF)
    Purification
    The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
    Clone
    Poly5242
    Isotype
    IgG
    Top Product
    Discover our top product CCL28 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Protect from prolonged exposure to light. Do not freeze.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    CCL28 (Chemokine (C-C Motif) Ligand 28 (CCL28))
    Alternative Name
    CCL28 (CCL28 Products)
    Synonyms
    Scya28 antibody, CCL28 antibody, ccl28 antibody, nrpb antibody, enc-1 antibody, pig10 antibody, Encr-3 antibody, klhl35 antibody, Xencr-3 antibody, tp53i10 antibody, LOC100303767 antibody, CCK1 antibody, MEC antibody, SCYA28 antibody, C-C motif chemokine ligand 28 antibody, ectodermal-neural cortex 1 (with BTB domain) antibody, C-C motif chemokine 28 antibody, chemokine (C-C motif) ligand 28 antibody, Ccl28 antibody, CCL28 antibody, ccl28 antibody, enc1 antibody, LOC100303767 antibody
    Background
    Mouse CCL28 was identified in an EST database using a human chemokine consensus sequence. CCL28 is constitutively expressed by mucosal epithelial cells such as exocrine glands, trachea, and colon. Acinar epithelial cells in human and mouse salivary glands are strongly positive for CCL28 by immunostaining, and human saliva and milk contain high concentrations of CCL28. Furthermore, it is known that human and mouse CCL28 have antimicrobial activity attributed to the C-terminus of CCL28 against Candida albicans, Gram-negative bacteria, and Gram-positive bacteria. In addition, using a CCR10 deficient mouse model, it was shown that CCR10 plays a critical role in localization and accumulation of IgA ASC in lactating mammary glands. Also, it has been described that CCL28 is upregulated in epithelial inflammation and this upregulation allows the recruitment of Tregs expressing CCR10. In fact, a subpopulation of CCR10-expressing CD25+ CD4+ Foxp3+ Tregs with potent anti-inflammatory properties was isolated from a chronically inflamed human liver. Information suggests that tumor hypoxia promotes the recruitment of Treg cells through induction of expression of CCL28, and this induction is mediated by the hypoxia inducible factor-1α (HIF-1α). Therefore, tumor hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells.
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