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SIGLEC8 antibody (APC)

SIGLEC8 Reactivity: Human FACS, ICFC Host: Mouse Monoclonal 7C9 APC
Catalog No. ABIN2658389
  • Target See all SIGLEC8 Antibodies
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    Reactivity
    • 42
    • 6
    • 2
    Human
    Host
    • 32
    • 9
    • 1
    Mouse
    Clonality
    • 34
    • 8
    Monoclonal
    Conjugate
    • 23
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIGLEC8 antibody is conjugated to APC
    Application
    • 32
    • 20
    • 19
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
    Purification
    The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
    Clone
    7C9
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product SIGLEC8 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Protect from prolonged exposure to light. Do not freeze.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    Alternative Name
    Siglec-8 (SIGLEC8 Products)
    Synonyms
    SAF2 antibody, SIGLEC-8 antibody, SIGLEC8L antibody, SIGLEC8 antibody, sialic acid binding Ig like lectin 8 antibody, sialic acid-binding Ig-like lectin 8 antibody, SIGLEC8 antibody, LOC506364 antibody
    Background
    Siglec-8 is a lectin specific for 6'-sulfo-sLex and a member of the Ig-superfamily. It is expressed almost exclusively in eosinophils, however, basophils and mast cells can express it to a lower degree. Siglec-8 is a 54 kD transmembranal protein, the extracellular domain has one V-set Ig-like domain and two C2-set domains. The cytoplasmic domain has two immunoreceptor tyrosine-based inhibitor motifs (ITIM) that recruit SH2-family phosphatases after tyrosine phosphorylation. There are reports that siglec-8 inhibits the release of histamine and prostaglandin D2 mediated by the IgEFcR. This molelcule is also involved in the induction of apoptosis.
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