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RANKL antibody (APC)
TNFSF11
Reactivity: Human
WB, ELISA
Host: Mouse
Monoclonal
MIH24
APC
Product Details anti-RANKL Antibody (APC)
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Target
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RANKL (TNFSF11)
(Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
Reactivity
All reactivities for RANKL antibodies
Human
Host
All hosts for RANKL antibodies
Mouse
Clonality
All clonalities for RANKL antibodies
Monoclonal
Conjugate
All conjugates for RANKL antibodies
This RANKL antibody is conjugated to APC
Application
All applications for RANKL antibodies
Western Blotting (WB), ELISA
Purification
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Clone
MIH24
Isotype
IgG2b kappa
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Discover our top product TNFSF11 Primary Antibody
Alternatives
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anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 210-317) antibody
TNFSF11
Reactivity: Human, Mouse, Rat, Rabbit
WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Protect from prolonged exposure to light. Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for RANKL
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Target
RANKL (TNFSF11)
(Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
Alternative Name
CD254 (TNFSF11 Products )
Synonyms
CD254 antibody, ODF antibody, OPGL antibody, OPTB2 antibody, RANKL antibody, TRANCE antibody, hRANKL2 antibody, sOdf antibody, TNFSF11 antibody, Ly109l antibody, OPG antibody, Trance antibody, cd254 antibody, odf antibody, opgl antibody, optb2 antibody, rankl antibody, sodf antibody, tnfsf11 antibody, trance antibody, TNF superfamily member 11 antibody, tumor necrosis factor (ligand) superfamily, member 11 antibody, TNF receptor superfamily member 11b antibody, TNF superfamily member 11 L homeolog antibody, TNFSF11 antibody, Tnfsf11 antibody, TNFRSF11B antibody, tnfsf11.L antibody
Background
Human CD254, also known as RANKL, TRANCE, and OPGL, is a type II transmembrane protein in the TNF superfamily that has two forms: a membrane-anchored protein and a secreted protein. Its extracellular domain is related to TRAIL, FasL, and TNF. CD254 is expressed on osteoclasts and activated T cells. It has been implicated in the regulation of the interactions between T cells and dendritic cells. It plays an important role in osteoclast differentiation and bone resorption. CD254 activates JNK and NF-κB and induces the expression of IL-1, IL-6, IL-12, and IL-15 in dendritic cells.
Pathways
NF-kappaB Signaling
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