IKZF2 antibody (Alexa Fluor 647)

Catalog No. ABIN2657915

Product Details anti-IKZF2 Antibody (Alexa Fluor 647)

Target: IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))

Reactivity: Human, Mouse

Host: Armenian Hamster

Clonality: Monoclonal

Conjugate: This IKZF2 antibody is conjugated to Alexa Fluor 647

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.

Clone: 22F6

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C

Target Details for IKZF2

Target: IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))

Alternative Name: Helios (IKZF2 Products)

Synonyms: ANF1A2 antibody, HELIOS antibody, ZNF1A2 antibody, ZNFN1A2 antibody, helios antibody, znf1a2 antibody, znfn1a1 antibody, znfn1a2 antibody, IKZF2 antibody, MGC159581 antibody, DKFZp469N0319 antibody, A730095J18Rik antibody, Helios antibody, Zfpn1a2 antibody, Znfn1a2 antibody, ikzf2 antibody, znfn1a1-a antibody, IKAROS family zinc finger 2 antibody, si:zfos-1425h8.1 antibody, IKAROS family zinc finger 2 (Helios) antibody, IKAROS family zinc finger 2 L homeolog antibody, IKZF2 antibody, ikzf2 antibody, Ikzf2 antibody, si:zfos-1425h8.1 antibody, ikzf2.L antibody

Background: Helios is a member of the Ikaros family of zinc finger transcription factors. It contains a C-terminal region composed of 2 zinc-finger domains that mediate dimerization between the family members. Helios was originally cloned from a mouse thymoma line. It is mainly expressed in peripheral T cells and thymocytes. It is found at high levels in a subpopulation of regulatory T cells. Helios plays an important role in T cell development and homeostasis. Overexpression of Helios profoundly alters αβ T cell differentiation and activation. It has been determined that silencing of Helios in B cells is critical for maintaining normal B cell function. Helios is also involved in tumor immunity.