Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

SPARC antibody

SPARC Reactivity: Human, Mouse WB, IHC (fro), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN265179
  • Target See all SPARC Antibodies
    SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))
    Reactivity
    • 85
    • 39
    • 35
    • 10
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 78
    • 20
    • 4
    • 2
    • 2
    Rabbit
    Clonality
    • 82
    • 24
    Polyclonal
    Conjugate
    • 59
    • 11
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SPARC antibody is un-conjugated
    Application
    • 85
    • 39
    • 29
    • 22
    • 13
    • 13
    • 11
    • 10
    • 9
    • 9
    • 7
    • 5
    • 5
    • 5
    • 5
    • 3
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects Human SPARC. May cross react with SPARCL1.
    Purification
    Antigen Immunoaffinity Chromatography
    Immunogen
    Synthetic peptide derived from the Human SPARC protein
    Top Product
    Discover our top product SPARC Primary Antibody
  • Application Notes
    ELISA. Western Blot: 0.5-1 μg/mL. Positive control: mouse heart lysate. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.274 mg/mL
    Buffer
    Phosphate buffered saline with 0.08 % Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Upon arrival freeze at -20 °C to -70 °C.
  • Target
    SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))
    Alternative Name
    SPARC / Osteonectin (SPARC Products)
    Synonyms
    ON antibody, AA517111 antibody, BM-40 antibody, hm:zeh0062 antibody, SPARC antibody, sparc antibody, secreted protein acidic and cysteine rich antibody, secreted acidic cysteine rich glycoprotein antibody, secreted protein, acidic, cysteine-rich (osteonectin) antibody, secreted protein, acidic, cysteine-rich (osteonectin) L homeolog antibody, secreted protein, acidic, cysteine-rich (osteonectin) S homeolog antibody, SPARC antibody, Sparc antibody, sparc antibody, sparc.L antibody, sparc.S antibody
    Background
    SPARC is a key factor in cell-matrix interactions and possibly tumour aggressiveness. The SPARC gene, which encodes a multifunctional glycoprotein with roles in tissue development, remodelling and fibrosis. A regulator of cell-extracellular matrix (ECM) interactions, SPARC represents a major factor in the ECM remodelling occurring during tumour invasion. in silico analysis reveals 4 UTR-SNPs located in the 3 -UTR of the SPARC gene, corresponding to 1474 g a, 1551 g c, 1922 t g and 2072 c t changes, which are significantly associated with tumoral state of the tissue. Of all hits, the 2072 SPARC polymorphism had the best association with cancer. SPARC therefore is a gene involved in a number of diseases including rheumatoid arthritis, scleroderma, tumor development and metastasis. SPARC variants have been detected in tumour samples of patients with acute myeloblastic leukemia (AML).Synonyms: BM-40, Basement-membrane protein 40, ON, Secreted protein acidic and rich in cysteine
    Gene ID
    6678
    NCBI Accession
    NP_003109
    UniProt
    P09486
    Pathways
    Autophagy
You are here:
Support