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Carboxy Methyl Lysine antibody (methylated)

CML EIA, WB Host: Goat Polyclonal unconjugated
Catalog No. ABIN264528
  • Target See all Carboxy Methyl Lysine (CML) Antibodies
    Carboxy Methyl Lysine (CML)
    Binding Specificity
    methylated
    Host
    • 2
    Goat
    Clonality
    • 2
    Polyclonal
    Conjugate
    • 2
    This Carboxy Methyl Lysine antibody is un-conjugated
    Application
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Enzyme Immunoassay (EIA), Western Blotting (WB)
    Purification
    CML-protein Sepharose affinity chromatography
    Immunogen
    Carboxymethylated Keyhole Limpet Hemocyanin (CML-KLH). Prepared by the reaction of the protein with glyoxylic acid.
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    Discover our top product CML Primary Antibody
  • Application Notes
    Western Blot. ELISA: 1: 4,000 - 1: 20,000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL (OD280nm, E0.1% = 1.35)
    Buffer
    75 mM PBS, pH 7.2 containing 75 mM Sodium chloride and 0.5 mM EDTA and 0.02 % Sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Carboxy Methyl Lysine (CML)
    Alternative Name
    Carboxy Methyl Lysine (CML Products)
    Synonyms
    ALL antibody, BCR1 antibody, CML antibody, D22S11 antibody, D22S662 antibody, PHL antibody, BCR, RhoGEF and GTPase activating protein antibody, BCR antibody
    Target Type
    Amino Acid
    Background
    Carboxymethyl Lysine is formed by the non enzymatic Schiff base reaction of glucose with proteins, followed by an Amadori rearrangement and oxidation that leaves only a carboxymethyl group attached to the lysine. The levels of CML adducts accumulate over time and have been used as an indicator of both serum glucose levels and oxidative protein damage. Elevated serum CML modified proteins have been associated with diabetes and may contribute to diabetic retinopathy, nephropathy and angiopathy.Synonyms: CML, Carboxymethyl-lysine
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