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Retinoblastoma 1 antibody (AA 393-572, AA 622-645)
RB1
Reactivity: Human, Mouse, Rat, Chicken, Mink
WB, IP
Host: Mouse
Monoclonal
XZ91
unconjugated
Product Details anti-Retinoblastoma 1 Antibody
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Target
See all Retinoblastoma 1 (RB1) Antibodies
Retinoblastoma 1 (RB1)
Binding Specificity
All epitopes for Retinoblastoma 1 antibodies
AA 393-572, AA 622-645
Reactivity
All reactivities for Retinoblastoma 1 antibodies
Human, Mouse, Rat, Chicken, Mink
Host
All hosts for Retinoblastoma 1 antibodies
Mouse
Clonality
All clonalities for Retinoblastoma 1 antibodies
Monoclonal
Conjugate
All conjugates for Retinoblastoma 1 antibodies
This Retinoblastoma 1 antibody is un-conjugated
Application
All applications for Retinoblastoma 1 antibodies
Western Blotting (WB), Immunoprecipitation (IP)
Specificity
Recognizes Retinoblastoma (Rb).
Characteristics
Synonyms: Retinoblastoma 1, Rb, p105-Rb, pRb, pp110, OSRC
Purification
Purified
Immunogen
Recombinant protein corresponding to amino acids 393-572 of the Human Retinoblastomasequence. Remarks: The epitope is contained within amino acids 622-645 of Humanretinoblastoma.
Clone
XZ91
Isotype
IgG1
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Discover our top product RB1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Western Blot. Immunoprecipitation. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Buffer
PBS containing 0.08 % Sodium Azide as preservative.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store the antibody (in aliquots) at -20 °C. Can be shipped at 2-8 °C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Expiry Date
12 months
Target Details for Retinoblastoma 1
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Target
Retinoblastoma 1 (RB1)
Alternative Name
Retinoblastoma-Associated Protein / RB1 (RB1 Products )
Synonyms
OSRC antibody, RB antibody, p105-Rb antibody, pRb antibody, pp110 antibody, Rb antibody, Rb-1 antibody, P105-RB antibody, PP110 antibody, RB11 antibody, zgc:154147 antibody, RB transcriptional corepressor 1 antibody, RB transcriptional corepressor like 1 antibody, retinoblastoma 1 antibody, RB1 antibody, RBL1 antibody, Rb1 antibody, rb1 antibody
Background
Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110
Gene ID
5925
UniProt
P06400
Pathways
Cell Division Cycle , Intracellular Steroid Hormone Receptor Signaling Pathway , Mitotic G1-G1/S Phases , DNA Replication , Maintenance of Protein Location , Synthesis of DNA , Autophagy
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