Valproic Acid antibody
EIA
Host: Mouse
Monoclonal
801
unconjugated
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- Target See all Valproic Acid products
- Valproic Acid
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Valproic Acid antibody is un-conjugated
- Application
- Enzyme Immunoassay (EIA)
- Purification
- Protein G chromatography
- Immunogen
- Valproic acid conjugated to KLH
- Clone
- 801
- Isotype
- IgG1
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- Application Notes
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May be used in immunoassays to detect and quantitate valproic acid.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.2mg/mL (OD280nm)
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
- Storage Comment
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Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - Expiry Date
- 12 months
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- Target
- Valproic Acid
- Abstract
- Valproic Acid Products
- Target Type
- Chemical
- Background
- Valproic acid, valproate sodium and divalproex belong to the group of medicines called anticonvulsants, used to control certain types of seizures in the treatment of epilepsy. Also, valproic acid relieves histone deacetylases (HDACs) dependent transcriptional repression and causes hyperacetylation of histones in cultured cells and in vivo. Valproic acid inhibits HDAC activity in vitro, most probably by binding to the catalytic centre of HDACs. Most importantly, valproic acid induces differentiation of carcinoma cells, transformed haematopoietic progenitor cells and leukaemic blasts from acute myeloid leukaemia patients. Moreover, tumour growth and metastasis formation are significantly reduced in animal experiments. Therefore, valproic acid might serve as an effective drug for cancer therapy.
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