CTXB antibody

Catalog No. ABIN263565

Product Details anti-CTXB Antibody

Target: CTXB (CtxB Gene Product (CTXB))

Reactivity: Vibrio cholerae

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTXB antibody is un-conjugated

Application: Enzyme Immunoassay (EIA), Western Blotting (WB)

Specificity: Reacts with cholera toxin beta subunit.

Characteristics: Synonyms: Cholera enterotoxin B chain, Cholera enterotoxin gamma chain, Choleragenoid, ctxB, toxB,VC_1456

Purification: Protein A Sepharose chromatography

Purity: > 90 % pure (SDS-PAGE)

Immunogen: Purified beta subunit of cholera toxin. Hybridization of Sp2/0 myeloma cells with spleencells from Balb/c mice.

Clone: B040M

Isotype: IgG2a

Application Details

Application Notes: ELISA. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4 containing 0.09 % Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CTXB

Target: CTXB (CtxB Gene Product (CTXB))

Alternative Name: Cholera Enterotoxin Subunit B (CTXB Products)

Background: The B subunit of cholera toxin (CtxB) binds to a GM1-ganglioside receptor, a ubiquitous glycolipid cell surface receptor. This binding is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin A subunit into cells. The beta chain has no toxic activity by itself. The holotoxin consists of a pentameric ring of B subunits whose central pore is occupied by the A subunit. The A subunit contains two chains, A1 and A2, linked by a disulfide bridge. The A subunit (and Cholera toxin) activates the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP.Synonyms: Cholera enterotoxin B chain, Cholera enterotoxin gamma chain, Choleragenoid, VC_1456, ctxB, toxB

Gene ID: 2613962

UniProt: P01556