TRPC3 antibody is human, mouse and rat reactive. At least four isoforms are known to exist, this antibody will detect the three largest isoforms. TRPC3 antibody is predicted to not cross-react with TRPC6.
Purification
TRPC3 Antibody is affinity chromatography purified via peptide column.
Immunogen
TRPC3 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human TRPC3.
The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.