TLR4 /MD2 Complex antibody

Catalog No. ABIN2568503

Product Details

Target: TLR4 /MD2 Complex

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func)

Specificity: The MTS510 monoclonal antibody specifically reacts with the Toll-Like Receptor 4 (TLR-4) and MD-2 (LY96) molecular complex.

Purification: The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/μg of the protein.

Clone: MTS510

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-buffered aqueous solution, ph7.2.

Storage: 4 °C

Storage Comment: The product should be stored undiluted at 4°C. Do not freeze.

Target Details

Target: TLR4 /MD2 Complex

Alternative Name: TLR4/MD-2 Complex

Background: The MTS510 monoclonal antibody specifically reacts with the Toll-Like Receptor 4 (TLR-4) and MD-2 (LY96) molecular complex. The complex of TLR-4, MD-2, and CD14 regulates the innate immune system recognition of bacterial lipopolysaccharides (LPS) and is expressed on the surface of thioglycollate-elicited macrophages. The epitope that binds the MTS510 antibody is lost after LPS stimulation and the antibody can be used to co-immunoprecipitates MD-2 and TLR4.

Gene ID: 21898

UniProt: Q9QUK6