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IZUMO1 antibody
IZUMO1
Reactivity: Human
ELISA, WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-IZUMO1 Antibody
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Target
See all IZUMO1 Antibodies
IZUMO1
(Izumo Sperm-Egg Fusion 1 (IZUMO1))
Reactivity
All reactivities for IZUMO1 antibodies
Human
Host
All hosts for IZUMO1 antibodies
Rabbit
Clonality
All clonalities for IZUMO1 antibodies
Polyclonal
Conjugate
All conjugates for IZUMO1 antibodies
This IZUMO1 antibody is un-conjugated
Application
All applications for IZUMO1 antibodies
ELISA, Western Blotting (WB)
Specificity
IZUMO1 antibody is human specific. At least four isoforms of IZUMO1 are known to exist, this antibody will detect the two longest isoforms.
Purification
IZUMO1 antibody is affinity chromatography purified via peptide column.
Immunogen
IZUMO1 antibody was raised against an 18 amino acid peptide near the center of human IZUMO1
Isotype
IgG
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Discover our top product IZUMO1 Primary Antibody
Alternatives
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Application Details
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Application Notes
IZUMO1 antibody can be used for detection of IZUMO1 by Western blot at 1 - 2 μ,g/mL.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
IZUMO1 antibody is supplied in PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C,4 °C
Storage Comment
IZUMO1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Target Details for IZUMO1
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Target
IZUMO1
(Izumo Sperm-Egg Fusion 1 (IZUMO1))
Alternative Name
IZUMO1 (IZUMO1 Products )
Synonyms
IZUMO antibody, 1700058F15Rik antibody, Izumo antibody, izumo sperm-egg fusion 1 antibody, Ras interacting protein 1 antibody, IZUMO1 antibody, RASIP1 antibody, Izumo1 antibody
Background
IZUMO1, a sperm-specific protein, is essential for sperm-egg plasma membrane binding and fusion. It is involved in the fertilization process and in the fusion of the sperm with the egg (1,2). IZUMO1 is expressed as at least four isoforms produced by alternative splicing and contains one Ig-like (immunoglobulin-like) C2-type domain (3). Lack of IZUMO1 in males, due to homozygous mutation in the gene that encodes IZUMO1, results in sterility due to an inability to penetrate the plasma membrane of the egg (4).
Molecular Weight
Predicted: 35, 39, 42 kDa Observed: 52 kDa
Gene ID
284359
NCBI Accession
NP_872381
UniProt
Q8IYV9
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