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eIF4EBP1 antibody (pThr70)
EIF4EBP1
Reactivity: Human
IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-eIF4EBP1 Antibody
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Target
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eIF4EBP1 (EIF4EBP1)
(Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
Binding Specificity
All epitopes for eIF4EBP1 antibodies
pThr70
Reactivity
All reactivities for eIF4EBP1 antibodies
Human
Host
All hosts for eIF4EBP1 antibodies
Rabbit
Clonality
All clonalities for eIF4EBP1 antibodies
Polyclonal
Conjugate
All conjugates for eIF4EBP1 antibodies
This eIF4EBP1 antibody is un-conjugated
Application
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Immunohistochemistry (IHC)
Specificity
The antibody detects endogenous levels of 4E-BP1 only when phosphorylated at threonine 70.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
4E-BP1 (phospho Thr70) antibody was raised against a peptide sequence around phosphorylation site of threonine70 (T-K-T (p)-P-P) derived from Human 4E-BP1.
Isotype
IgG
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for eIF4EBP1
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Target
eIF4EBP1 (EIF4EBP1)
(Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
Alternative Name
4E-BP1 (EIF4EBP1 Products )
Synonyms
4E-BP1 antibody, 4EBP1 antibody, BP-1 antibody, PHAS-I antibody, 4e-bp1 antibody, AA959816 antibody, 153432_at antibody, 43-BP antibody, 4E-BP antibody, 4EBP antibody, 4e-bp antibody, 4eBP antibody, 4ebp antibody, BcDNA.HL08053 antibody, BcDNA:HL08053 antibody, CG8846 antibody, CT8705 antibody, Dm 4E-BP antibody, Dmel\\CG8846 antibody, Phas1 antibody, Thor/EIF4EBP antibody, anon-WO0172774.158 antibody, d4E-BP antibody, d4E-BP1 antibody, d4EBP antibody, d4e-bp antibody, d4eBP antibody, dthor antibody, eIF4E-BP antibody, l(2)06270 antibody, l(2)k07736 antibody, l(2)k13517 antibody, pp20 antibody, thor antibody, EIF4EBP1 antibody, fc04h09 antibody, wu:fc04h09 antibody, zgc:64137 antibody, eukaryotic translation initiation factor 4E binding protein 1 antibody, CG8846 gene product from transcript CG8846-RA antibody, EIF4EBP1 antibody, Eif4ebp1 antibody, Thor antibody, eif4ebp1 antibody
Background
4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Molecular Weight
12 kDa
Gene ID
1978
NCBI Accession
NP_004086
UniProt
Q13541
Pathways
MAPK Signaling , PI3K-Akt Signaling , RTK Signaling , AMPK Signaling , Regulation of Cell Size , BCR Signaling
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