Leptin Receptor antibody (AA 901-1000) (PE)

Catalog No. ABIN2559727

Product Details anti-Leptin Receptor Antibody (PE)

Target: Leptin Receptor (LEPR)

Binding Specificity: AA 901-1000

Reactivity: Human, Mouse, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Leptin Receptor antibody is conjugated to PE

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificity: This antibody will recognize the Isoform B variant only

Cross-Reactivity: Human, Mouse, Pig, Rat

Predicted Reactivity: Dog,Cow,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Leptin receptor:901-1000/1165

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

References for anti-Leptin Receptor antibody (PE) (ABIN2559727)

Goto, Kaneko, Sato, Otsuka, Yamamoto, Goto, Yamamoto, Yamamoto, Kawachi, Madaio, Narita: "Leptin deficiency down-regulates IL-23 production in glomerular podocytes resulting in an attenuated immune response in nephrotoxic serum nephritis." in: International immunology, Vol. 28, Issue 4, pp. 197-208, (2016) (PubMed).

Target Details for Leptin Receptor

Target: Leptin Receptor (LEPR)

Alternative Name: Leptin receptor (Isoform B) (LEPR Products)

Synonyms: CD295 antibody, LEP-R antibody, LEPRD antibody, OB-R antibody, OBR antibody, obr antibody, cd295 antibody, ob-rb antibody, Fa antibody, LEPROT antibody, Leprb antibody, Modb1 antibody, OB-RGRP antibody, Obr antibody, db antibody, diabetes antibody, obese-like antibody, obl antibody, ObRb antibody, Ob-R antibody, Ob-RM antibody, lepr antibody, leptin receptor antibody, leptin receptor S homeolog antibody, LEPR antibody, lepr antibody, Lepr antibody, lepr.S antibody

Background:

Synonyms: OBR, OB-R, CD295, LEP-R, LEPRD, Leptin receptor, HuB219, OB receptor, LEPR, DB, LEPR_MOUSE

Background: Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).

Gene ID: 3953

UniProt: P48357

Pathways: JAK-STAT Signaling, AMPK Signaling, Feeding Behaviour