NLRP6 antibody (AA 351-450)

Catalog No. ABIN2559652

Product Details anti-NLRP6 Antibody

Target: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Binding Specificity: AA 351-450

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP6 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NALP6

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
IP(1-2 μg)
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for NLRP6

Target: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Alternative Name: NALP6 (NLRP6 Products)

Synonyms: NLRP6 antibody, NALP6 antibody, AVR antibody, CLR11.4 antibody, NAVR antibody, NAVR/AVR antibody, PAN3 antibody, PYPAF5 antibody, AI504961 antibody, Avr antibody, Nalp6 antibody, Navr antibody, Navr/Avr antibody, Pypaf5 antibody, NLR family pyrin domain containing 6 antibody, NLR family, pyrin domain containing 6 antibody, NLRP6 antibody, Nlrp6 antibody

Background:

Synonyms: AVR, NAVR, PAN3, NALP6, PYPAF5, CLR11.4, NAVR/AVR, NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5, NLRP6

Background: May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine-vasopressin but not angiotensin II and acts as an arginine-vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation (By similarity).

Gene ID: 171389

UniProt: P59044

Pathways: Inflammasome