TMEM30A antibody (AA 251-350) (Biotin)

Catalog No. ABIN2559506

Product Details anti-TMEM30A Antibody (Biotin)

Target: TMEM30A (Transmembrane Protein 30A (TMEM30A))

Binding Specificity: AA 251-350

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM30A antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Transmembrane protein 30A

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for TMEM30A

Target: TMEM30A (Transmembrane Protein 30A (TMEM30A))

Alternative Name: Transmembrane protein 30A (TMEM30A Products)

Synonyms: tmem30a antibody, wu:fj66b08 antibody, zgc:91877 antibody, fi23a10 antibody, wu:fb15c10 antibody, wu:fi23a10 antibody, zgc:55379 antibody, zgc:77655 antibody, cg9947 antibody, MGC53259 antibody, MGC75889 antibody, CDC50A antibody, DKFZp459A091 antibody, DKFZp459D097 antibody, DKFZp459B0431 antibody, C6orf67 antibody, 2010200I23Rik antibody, AW540225 antibody, Cdc50a antibody, D9Wsu20e antibody, transmembrane protein 30Aa antibody, transmembrane protein 30A antibody, transmembrane protein 30Ab antibody, transmembrane protein 30A L homeolog antibody, tmem30aa antibody, TMEM30A antibody, tmem30ab antibody, tmem30a.L antibody, tmem30a antibody, LOAG_03933 antibody, Tmem30a antibody

Background:

Synonyms: CDC50A, C6orf67, Cell cycle control protein 50A, P4-ATPase flippase complex beta subunit TMEM30A, Transmembrane protein 30A, TMEM30A

Background: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations.

Gene ID: 55754

UniProt: Q9NV96