NPAS4 antibody (AA 597-802) (Atto 390)

Catalog No. ABIN2485807

Product Details anti-NPAS4 Antibody (Atto 390)

Target: NPAS4 (Neuronal PAS Domain Protein 4 (NPAS4))

Binding Specificity: AA 597-802

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This NPAS4 antibody is conjugated to Atto 390

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: Highly expressed in the brain, with lower expression found in endocrine tissue.,Detects ~90 kDa.

Cross-Reactivity: Human, Mouse, Rat

Purification: Protein G Purified

Immunogen: Fusion protein amino acids 597-802 (C-terminus) of rat Npas4.

Clone: S408-79

Isotype: IgG1

Application Details

Application Notes:

• WB (1:1000)
• ICC/IF(1:100)
• optimal dilutions for assays should be determined by the user.

Comment:

A 1:100 dilution of ABIN2485807 was sufficient for detection of NPAS4 in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Conjugated antibodies should be stored at 4°C

Target Details for NPAS4

Target: NPAS4 (Neuronal PAS Domain Protein 4 (NPAS4))

Alternative Name: NPAS4 (NPAS4 Products)

Synonyms: LE-PAS antibody, Nxf antibody, Le-PAS antibody, NXF antibody, PASD10 antibody, bHLHe79 antibody, npas4 antibody, wu:fj52d04 antibody, zgc:136764 antibody, MGC146621 antibody, neuronal PAS domain protein 4 antibody, neuronal PAS domain protein 4a antibody, neuronal PAS domain-containing protein 4 antibody, Npas4 antibody, NPAS4 antibody, npas4a antibody, npas4 antibody, Tsp_02837 antibody

Background: NPAS4 belongs to the Per-Arnt-Sim family of neuronal specific transciption factors, all involved in the development and maintenance of learning and memory pathways (1). NPAS4 is a transcription factor that regulates the formation and maintenance of inhibitory synapses, and can activate the CNS midline enhancer element and the expression of the drebrin gene. Deregulation has been to be associated with developmental disorders such as schizophrenia and autism (2).

Gene ID: 266734

NCBI Accession: NP_705890

UniProt: Q8CJH6