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SPTBN4 antibody (AA 1621-1832) (APC)

SPTBN4 Reactivity: Human IHC, WB, ICC, IF Host: Mouse Monoclonal S393-2 APC
Catalog No. ABIN2485673
  • Target See all SPTBN4 Antibodies
    SPTBN4 (Spectrin Beta, Non-Erythrocytic 4 (SPTBN4))
    Binding Specificity
    • 10
    • 1
    • 1
    • 1
    AA 1621-1832
    Reactivity
    • 13
    • 1
    • 1
    • 1
    Human
    Host
    • 11
    • 1
    • 1
    Mouse
    Clonality
    • 11
    • 2
    Monoclonal
    Conjugate
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SPTBN4 antibody is conjugated to APC
    Application
    • 12
    • 12
    • 11
    • 9
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    Detects ~>200 kDa. Does not cross react with other Beta-spectrins
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin
    Clone
    S393-2
    Isotype
    IgG1
    Top Product
    Discover our top product SPTBN4 Primary Antibody
  • Application Notes
    • WB (1:1000)
    • optimal dilutions for assays should be determined by the user.
    Comment

    A 1:100 dilution of ABIN2485673 was sufficient for detection of Beta 4 Spectrin in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    SPTBN4 (Spectrin Beta, Non-Erythrocytic 4 (SPTBN4))
    Alternative Name
    beta 4 Spectrin (SPTBN4 Products)
    Synonyms
    qv antibody, dyn antibody, lnd antibody, SpbIV antibody, ROSA62 antibody, nmf261 antibody, nmf379 antibody, 1700022P15Rik antibody, 5830426A08Rik antibody, Spnb4 antibody, QV antibody, SPNB4 antibody, SPTBN3 antibody, spectrin beta, non-erythrocytic 4 antibody, spectrin, beta, non-erythrocytic 4 antibody, Sptbn4 antibody, SPTBN4 antibody
    Background
    Spectrin is the major constituent of the cytoskeletal network underlying the erthrocyte plasma membrane and determines cell shape, arrangement of transmembrane proteins and organization of organelles. It is expressed at very low levels in many tissues, with the strongest expression in the cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder and heart (1). Spectrin beta 4 is a non-erythrocyte member, and is expressed in the brain and pancreatic islets and localisted to the nuclear matrix, cytoplasmic vesicles and PML nuclear bodies. Beta4 spectrins are also essential for membrane stability and the molecular organization of the nodes of Ranvier (2).
    Gene ID
    57731
    NCBI Accession
    NP_066022
    UniProt
    Q9H254
    Pathways
    Sensory Perception of Sound, Regulation of Actin Filament Polymerization, Maintenance of Protein Location
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