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SHANK2 antibody (AA 84-309) (APC)

SHANK2 Reactivity: Rat WB, IHC, IP, IF, ICC, AA Host: Mouse Monoclonal N23b-49 (Formerly S23b-49) APC
Catalog No. ABIN2484048
  • Target See all SHANK2 Antibodies
    SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))
    Binding Specificity
    • 27
    • 15
    • 10
    • 8
    • 7
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 84-309
    Reactivity
    • 45
    • 33
    • 33
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 47
    • 31
    • 1
    Mouse
    Clonality
    • 49
    • 30
    Monoclonal
    Conjugate
    • 27
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SHANK2 antibody is conjugated to APC
    Application
    • 72
    • 34
    • 29
    • 25
    • 20
    • 20
    • 16
    • 13
    • 13
    • 10
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)
    Specificity
    Detects ~160 kDa. Recognizes Shank1, 2 and 3.
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Protein G Purified
    Immunogen
    Fusion protein amino acids 84-309 of rat Shank2
    Clone
    N23b-49 (Formerly S23b-49)
    Isotype
    IgG1
    Top Product
    Discover our top product SHANK2 Primary Antibody
  • Application Notes
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    1 μg/ml of ABIN2484048 was sufficient for detection of Shank1-4 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))
    Alternative Name
    SHANK (SHANK2 Products)
    Synonyms
    AUTS17 antibody, CORTBP1 antibody, CTTNBP1 antibody, ProSAP1 antibody, SHANK antibody, SPANK-3 antibody, mKIAA1022 antibody, auts17 antibody, cortbp1 antibody, cttnbp1 antibody, prosap1 antibody, spank-3 antibody, shank2 antibody, MGC122482 antibody, CortBP1 antibody, Spank-3 antibody, SHANK2 antibody, SH3 and multiple ankyrin repeat domains 2 antibody, SH3 and multiple ankyrin repeat domains 2 L homeolog antibody, SH3 and multiple ankyrin repeat domains protein 2 antibody, SHANK2 antibody, Shank2 antibody, shank2.L antibody, shank2 antibody, LOC100438523 antibody
    Background
    Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).
    Gene ID
    171093
    UniProt
    Q9QX74
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