HCN1 antibody (AA 778-910) (Biotin)

Catalog No. ABIN2483964

Product Details anti-HCN1 Antibody (Biotin)

Target: HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))

Binding Specificity: AA 778-910

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This HCN1 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Antibody Array (AA)

Specificity: Detects ~100 kDa. No cross-reactivity against HCN2.

Cross-Reactivity: Human, Mouse, Rat

Purification: Protein G Purified

Immunogen: Fusion protein amino acids 778-910 (C terminus) of rat HCN1

Clone: S70

Isotype: IgG1

Application Details

Application Notes:

• WB (1:1000)
• IHC (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Comment:

1 μg/ml of ABIN2483964 was sufficient for detection of HCN1 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Conjugated antibodies should be stored at 4°C

Target Details for HCN1

Target: HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))

Alternative Name: HCN1 (HCN1 Products)

Synonyms: BCNG-1 antibody, BCNG1 antibody, HAC-2 antibody, Bcng1 antibody, C630013B14Rik antibody, HAC2 antibody, hyperpolarization activated cyclic nucleotide gated potassium channel 1 antibody, hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 antibody, hyperpolarization-activated, cyclic nucleotide-gated K+ 1 antibody, hcn1 antibody, HCN1 antibody, Hcn1 antibody

Background: Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, play a crucial role in the regulatons of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in both the heart and brain (1).

Gene ID: 84390

NCBI Accession: NP_445827

UniProt: Q9JKB0

Pathways: Asymmetric Protein Localization