NALCN antibody (AA 1659-1738) (Atto 390)
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- Target See all NALCN Antibodies
- NALCN (Sodium Leak Channel, Non-Selective (NALCN))
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Binding Specificity
- AA 1659-1738
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Reactivity
- Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This NALCN antibody is conjugated to Atto 390
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Application
- Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificity
- Detects ~200 kDa.
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Protein G Purified
- Immunogen
- Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN
- Clone
- S187-7
- Isotype
- IgG1
- Top Product
- Discover our top product NALCN Primary Antibody
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- Application Notes
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- WB (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- Comment
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1 μg/ml of ABIN2483019 was sufficient for detection of NALCN in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Conjugated antibodies should be stored at 4°C
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- Target
- NALCN (Sodium Leak Channel, Non-Selective (NALCN))
- Alternative Name
- NALCN (NALCN Products)
- Synonyms
- VGCNL1 antibody, zgc:113349 antibody, CanIon antibody, bA430M15.1 antibody, A530023G15Rik antibody, AI849508 antibody, Vgcnl1 antibody, sodium leak channel, non-selective antibody, NALCN antibody, nalcn antibody, Nalcn antibody
- Background
- NALCN (sodium leak channel non-selective protein), alsoknown as CanIon or VGCNL1 (voltage gated channel-like protein 1), is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCN is highly conserved in mammals and is widely expressed in the central nervous system. Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable to sodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exists due to alternative splicing events.
- Gene ID
- 266760
- NCBI Accession
- NP_705894
- UniProt
- Q6Q760
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