ABCC8 antibody (AA 1548-1582) (Atto 390)
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- Target See all ABCC8 Antibodies
- ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
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Binding Specificity
- AA 1548-1582
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Reactivity
- Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This ABCC8 antibody is conjugated to Atto 390
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificity
- Detects ~160 kDa. Does not cross-react with SUR2B.
- Cross-Reactivity
- Hamster, Human, Mouse, Rat
- Purification
- Protein G Purified
- Immunogen
- Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
- Clone
- S289-16
- Isotype
- IgG1
- Top Product
- Discover our top product ABCC8 Primary Antibody
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- Application Notes
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- WB (1:1000)
- IHC (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- Comment
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1 μg/ml of ABIN2482985 was sufficient for detection of SUR1 in 20 μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Conjugated antibodies should be stored at 4°C
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- Target
- ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
- Alternative Name
- SUR1 (ABCC8 Products)
- Synonyms
- ABC36 antibody, HHF1 antibody, HI antibody, HRINS antibody, MRP8 antibody, PHHI antibody, SUR antibody, SUR1 antibody, SUR1delta2 antibody, TNDM2 antibody, D930031B21Rik antibody, Sur antibody, Sur1 antibody, ATP binding cassette subfamily C member 8 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 8 antibody, ABCC8 antibody, Abcc8 antibody
- Background
- Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2) (1). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell (2).
- Gene ID
- 25559
- NCBI Accession
- NP_037171
- UniProt
- Q09429
- Pathways
- Negative Regulation of Hormone Secretion
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