AHSA1 antibody (Atto 594)

Catalog No. ABIN2481465

Product Details anti-AHSA1 Antibody (Atto 594)

Target: AHSA1 (Activator of HSP90 ATPase Activity 1 (AHSA1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This AHSA1 antibody is conjugated to Atto 594

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: Detects ~38 kDa. Can run up to 45 kDa on SDS Page.

Cross-Reactivity: Human, Mouse, Rat

Purification: Protein G Purified

Immunogen: Recombinant Full Length Mouse Aha1 Protein

Clone: 25F2-D9

Isotype: IgG2a kappa

Application Details

Application Notes:

• WB (1:1000)
• IHC (1:100)
• ICC/IF (1:1000)
• IP (1:1000)
• optimal dilutions for assays should be determined by the user.

Comment:

1 μg/ml of ABIN2481465 was sufficient for detection of Aha1 in 10 μg of rat tissue lysate by colorimetric immunoblot analysis using Goat anti-rat IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.2 mg/mL

Buffer: 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2, Storage buffer may change when conjugated

Storage: 4 °C

Storage Comment: Conjugated antibodies should be stored at 4°C

Target Details for AHSA1

Target: AHSA1 (Activator of HSP90 ATPase Activity 1 (AHSA1))

Alternative Name: AHA1 (AHSA1 Products)

Synonyms: ahsa1 antibody, MGC52884 antibody, MGC132147 antibody, MGC80312 antibody, AHSA1 antibody, MGC89589 antibody, wu:fb83b05 antibody, zgc:136821 antibody, zgc:56075 antibody, AHA1 antibody, C14orf3 antibody, p38 antibody, BC023857 antibody, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 S homeolog antibody, activator of Hsp90 ATPase activity 1 antibody, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 L homeolog antibody, activator of HSP90 ATPase activity 1 antibody, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 antibody, AHA1, activator of heat shock protein ATPase homolog 1a antibody, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) antibody, AHA1, activator of heat shock protein ATPase 1 antibody, ahsa1.S antibody, AHSA1 antibody, ahsa1.L antibody, ahsa1 antibody, ahsa1a antibody, Ahsa1 antibody

Background: Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).

Gene ID: 217737

NCBI Accession: NP_666148

UniProt: Q8BK64