APAF1 antibody (AA 12-28)

Catalog No. ABIN2477457

Product Details anti-APAF1 Antibody

Target: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Binding Specificity: AA 12-28

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APAF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Apaf1 (Apoptosis protease activating factor 1) is the mammalian homologue of the CED-4 cell death protein in C. Elegans. Apaf1 binds to cytochrome C and caspase-9 leading to caspase-9 activation, resulting in the beginning of the proteolytic cascade characteristic of apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. AHP487 recognises a 130kD band in Western blots.

Cross-Reactivity: Mouse (Murine)

Characteristics: Purified IgG

Purification: Purified

Immunogen: Synthetic peptide corresponding to amino acids 12-28 of human Apaf1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Target Details for APAF1

Target: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Alternative Name: APAF1 (APAF1 Products)

Gene ID: 317

UniProt: O14727

Pathways: p53 Signaling, Apoptosis, Caspase Cascade in Apoptosis, Tube Formation, Positive Regulation of Endopeptidase Activity