Endothelin antibody (C-Term)
Reactivity: Human
IHC (fro), IRMA
Host: Rat
Monoclonal
3G10
unconjugated
(1 reference)-
- Target See all Endothelin Antibodies
- Endothelin
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Binding Specificity
- C-Term
-
Reactivity
- Human
-
Host
- Rat
-
Clonality
- Monoclonal
-
Conjugate
- This Endothelin antibody is un-conjugated
-
Application
- Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoradiometric Assay (IRMA)
- Specificity
- Reacts with the C terminal of endothelins 1, 2 and 3. 3G10 does not react with the endothelin precursor molecule, big endothelin. The endothelins are potent vasoconstrictors and critical components in the progression of pulmonary arterial hypertension a devastating and rapidly progressive condition that leads to right ventricular strain and dysfunction.
- Characteristics
- Purified IgG
- Purification
- Purified
- Immunogen
- Synthetic peptide corresponding to the c-terminal region of human endothelin (C,H,L,D,I,I,W), conjugated to BSA.
- Clone
- 3G10
- Isotype
- IgG2b
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-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1.0 mg/mL
-
-
: "Endothelin is a potent inhibitor of matrix metalloproteinase-2 secretion and activation in rat mesangial cells." in: American journal of physiology. Renal physiology, Vol. 280, Issue 4, pp. F628-35, (2001) (PubMed).
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: "Endothelin is a potent inhibitor of matrix metalloproteinase-2 secretion and activation in rat mesangial cells." in: American journal of physiology. Renal physiology, Vol. 280, Issue 4, pp. F628-35, (2001) (PubMed).
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- Target
- Endothelin
- Abstract
- Endothelin Products
- Gene ID
- 1906, 1907, 1908
- UniProt
- P05305, P14138, P20800
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