SNW1 antibody

Catalog No. ABIN2460414

Product Details anti-SNW1 Antibody

Target: SNW1 (SNW Domain Containing 1 (SNW1))

Reactivity: Human, Dog, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNW1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SKIIP.

Application Details

Application Notes: SKIIP antibody can be used for detection of SKIIP by ELISA at 1:62500. SKIIP antibody can be used for detection of SKIIP by western blot at 1.0-5.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store SKIIP antibody at -20 °C.

Target Details for SNW1

Target: SNW1 (SNW Domain Containing 1 (SNW1))

Alternative Name: SKIIP (SNW1 Products)

Background: SKIIP (Nuclear Protein SkiP, nuclear receptor coactivator NCoA-62, ski-interacting protein) is a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also interact with poly (A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.

Molecular Weight: 61 kDa

Gene ID: 22938

NCBI Accession: NP_036377

UniProt: Q13573

Pathways: Retinoic Acid Receptor Signaling Pathway