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SUMO2/3 antibody (full length)

SUMO2/3 Reactivity: Human, Mouse, Rat WB, IF, ELISA, IHC (fro) Host: Rat Monoclonal 3H12 unconjugated
Catalog No. ABIN2452139
  • Target See all SUMO2/3 products
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Binding Specificity
    • 16
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    full length
    Reactivity
    • 48
    • 13
    • 13
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 38
    • 10
    Rat
    Clonality
    • 30
    • 18
    Monoclonal
    Conjugate
    • 14
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SUMO2/3 antibody is un-conjugated
    Application
    • 41
    • 24
    • 14
    • 14
    • 14
    • 13
    • 10
    • 7
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    Specific to SUMO2 and SUMO3 of human, simian, mouse, hamster and rat. Does not react with SUMO1. This antibody recognizes both SUMO2 and SUMO3, but not SUMO1.
    Cross-Reactivity (Details)
    Not tested for other species
    Purification
    The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.
    Sterility
    Sterile filtered
    Immunogen
    Recombinant GST-fused human SUMO3 (full length)
    Clone
    3H12
    Isotype
    IgG2a kappa
  • Application Notes
    1. Western blotting: 1/1,000
    2. Immunocytochemistry/Immunofluorescence staining: 1/100~1/500
    3. Immunohistochemistry,frozen section: 1/100~1/500
    4. ELISA (Assay dependent concentration)
    Other applications have not been tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS (x1), 50 % glycerol. Azide and carrier free.
    Preservative
    Azide free
    Storage
    -20 °C
    Storage Comment
    Upon arrival centrifuge briefly and store at -20 C.
  • Uchimura, Ichimura, Uwada, Tachibana, Sugahara, Nakao, Saitoh: "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation." in: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23180-90, (2006) (PubMed).

  • Target
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Alternative Name
    SUMO2/3 (SUMO2/3 Products)
    Synonyms
    SUMO2 antibody, small ubiquitin-like modifier 2 antibody, SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)-like antibody, small ubiquitin-related modifier 2 antibody, SUMO2 antibody, LOC711990 antibody, LOC714892 antibody
    Background
    SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. Unlike ubiquitination, which targets proteins for degradation, SUMO modification plays a critical role in a number of cellular functions including nucleocytoplasmic transport, gene expression, cell cycle and formation of subnuclear structures such as promyelocytic leukemia (PML) bodies. There are three confirmed SUMO isoforms in human, SUMO1, SUMO2 and SUMO3. SUMO2 and 3 show a high degree of similarity to each other and are distinct from SUMO1. Individual SUMO family members are all targeted to different proteins with diverse biological functions. SUMO2/3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, and regulates chromosomal segregation and cellular responses to environmental stress.
    Molecular Weight
    10,871 Da with 95 AA, 11,637 Da with 103 AA
    UniProt
    P61956, P55854
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