PRNP antibody

Catalog No. ABIN2452080

Product Details anti-PRNP Antibody

Target: PRNP (Prion Protein (PRNP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRNP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): Does not react with mouse Prion. Not tested with other species

Purification: Purified

Sterility: Sterile filtered

Immunogen: Recombinant human PrP lacking GPI anchor expressed and purified from rabbit kidney cell line RK13

Clone: 2C5-5

Isotype: IgG

Application Details

Application Notes: 1) Western blotting: ~0. 5 g/mL
2) ELISA (most suitable)
Other applications have not been tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Preservative: Azide free

Storage: -20 °C

References for anti-PRNP antibody (ABIN2452080)

Sakudo, Nakamura, Ikuta, Onodera: "Recent developments in prion disease research: diagnostic tools and in vitro cell culture models." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Vol. 69, Issue 4, pp. 329-37, (2007) (PubMed).

Target Details for PRNP

Target: PRNP (Prion Protein (PRNP))

Alternative Name: Prion Protein (PRNP Products)

Synonyms: ASCR antibody, AltPrP antibody, CD230 antibody, CJD antibody, GSS antibody, KURU antibody, PRIP antibody, PrP antibody, PrP27-30 antibody, PrP33-35C antibody, PrPc antibody, p27-30 antibody, Prn antibody, Prn-p antibody, prp antibody, cjd antibody, prion antibody, prp(c) antibody, MGC84114 antibody, PRP antibody, PRPC antibody, Prp antibody, SIP antibody, PRNP antibody, AA960666 antibody, AI325101 antibody, PrP antibody, PrPC antibody, PrPSc antibody, Prn-i antibody, Sinc antibody, prP27-30 antibody, prP33-35C antibody, PrP-1 antibody, PrP1 antibody, prnprs1 antibody, stPrP-1 antibody, zgc:123004 antibody, prion protein antibody, prion protein S homeolog antibody, prion protein b antibody, PRNP antibody, Prnp antibody, prnp.S antibody, prnpb antibody

Background: Prion protein PrP is a membrane glycosylphosphatidylinositol(GPI) anchored glycoprotein highly expressed in neuron and glia cells as well as immune and reproductive cells. Mutations in the octapeptide repeat regions as well as elsewhere in this gene have been associated with neurodegenerative diseases such as Creutzfeldt Jakob disease, fatal familial insomnia, Gerstmann Straussler disease, Huntington disease like 1, and kuru. The infectious isoform of PrPC, known as PrPSc, is able to convert normal PrPPC proteins into the infectious isoform, which is insoluble amyloid aggregate, by changing their. Mature PrP protein in human consists of 209 amino acids. Several forms exist, one cell surface form anchored via and two forms, therefore multiple bands are observed in SDS-PAGE (Figure). conformation topological glycolipid transmembrane

UniProt: P04156

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation