MSS4 antibody, STM7 antibody, AI844522 antibody, Pip5k1a antibody, Pipk5a antibody, Pipk5b antibody, MGC80809 antibody, pip5k1b antibody, zgc:101046 antibody, wu:fj29b05 antibody, wu:fj93b05 antibody, zgc:92316 antibody, phosphatidylinositol-4-phosphate 5-kinase type 1 beta antibody, phosphatidylinositol-4-phosphate 5-kinase, type 1 beta antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, beta L homeolog antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, beta a antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, beta antibody, phosphatidylinositol 4-phosphate 5-kinase type-1 beta antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, beta b antibody, PIP5K1B antibody, Pip5k1b antibody, pip5k1b.L antibody, pip5k1ba antibody, pip5k1b antibody, LOC100472550 antibody, pip5k1bb antibody
Background
Phosphatidylinositol-4-phosphate-5-kinase (PIPK) synthesizes phosphatidylinositol-4,5-bisphosphate, which regulates various processes including cell proliferation, survival, membrane trafficking, and cytoskeletal organization. The PIPK family is divided into type I, type II and type III . Each type of the PIPK family phosphorylate distinct substrates and they contain an activation loop, which determines their enzymatic specificity and subcellular targeting . The phosphatidylinositol-4-phosphate-5-kinase type I consists of three members, PIPK I , , and , which are characterized by phosphorylating PI4P on the 5-hydroxyl . PIPK I (designated PIPK I in mouse) is expressed in brain tissue . PIPK I , designated PIPK I a in mouse, is also called STM7. PIPK I has two variants produced by alternative splicing which are expressed in lung, brain, and kidneys.