×
For best experience we recommend to activate Javascript in your browser.
Calreticulin antibody
CALR
Reactivity: Human, Mouse, Rat
WB, ELISA, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Calreticulin Antibody
(hide)
Target
See all Calreticulin (CALR) Antibodies
Calreticulin (CALR)
Reactivity
All reactivities for Calreticulin antibodies
Human, Mouse, Rat
Host
All hosts for Calreticulin antibodies
Rabbit
Clonality
All clonalities for Calreticulin antibodies
Polyclonal
Conjugate
All conjugates for Calreticulin antibodies
This Calreticulin antibody is un-conjugated
Application
All applications for Calreticulin antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
Purification
Affinity purification
Immunogen
Recombinant protein of human CALR
Isotype
IgG
Top Product
Discover our top product CALR Primary Antibody
Alternatives
(show)
Application Details
(hide)
Application Notes
WB 1:1000-1:5000, IHC 1:50-1:200
Restrictions
For Research Use only
Handling
(hide)
Format
Liquid
Concentration
0.2 mg/mL
Buffer
PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
Preservative
Sodium azide
Handling Advice
Avoid freeze / thaw cycles.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for Calreticulin
(hide)
Target
Calreticulin (CALR)
Alternative Name
CALR (CALR Products )
Synonyms
CRT antibody, RO antibody, SSA antibody, cC1qR antibody, crc antibody, crt antibody, Calregulin antibody, CG9429 antibody, Clr antibody, Dmel\\CG9429 antibody, anon-EST:Liang-2.11 antibody, anon-EST:Liang-2.17 antibody, anon-EST:fe3D7 antibody, clone 2.11 antibody, clone 2.17 antibody, eth antibody, potp antibody, cc1qr antibody, ssa antibody, NV19007 antibody, CRP55 antibody, ERp60 antibody, HACBP antibody, CHOT1 antibody, CHT1 antibody, CT1 antibody, AA589632 antibody, CRTR antibody, Creat antibody, CCDS1 antibody, calrl2 antibody, fc66d10 antibody, wu:fc66d10 antibody, wu:fj50c03 antibody, zgc:66153 antibody, calreticulin antibody, calreticulin L homeolog antibody, Calreticulin antibody, putative calreticulin antibody, solute carrier family 6 member 8 antibody, solute carrier family 6 (neurotransmitter transporter, creatine), member 8 antibody, CALR antibody, calr.L antibody, Crt antibody, crt antibody, CRT antibody, Calr antibody, calr antibody, LMJF_31_2600 antibody, Crc antibody, Slc6a8 antibody, SLC6A8 antibody, LOC8269812 antibody
Background
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.
Molecular Weight
Calculated MW: 48 kDa
Pathways
Retinoic Acid Receptor Signaling Pathway , Intracellular Steroid Hormone Receptor Signaling Pathway , Regulation of Intracellular Steroid Hormone Receptor Signaling , Nuclear Hormone Receptor Binding , ER-Nucleus Signaling , Unfolded Protein Response
Recently viewed
(hide)