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GCK antibody
GCK
Reactivity: Human, Mouse, Rat
WB, ELISA, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-GCK Antibody
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Target
See all GCK Antibodies
GCK
(Glucokinase (Hexokinase 4) (GCK))
Reactivity
All reactivities for GCK antibodies
Human, Mouse, Rat
Host
All hosts for GCK antibodies
Rabbit
Clonality
All clonalities for GCK antibodies
Polyclonal
Conjugate
All conjugates for GCK antibodies
This GCK antibody is un-conjugated
Application
All applications for GCK antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
Purification
Affinity purification
Immunogen
Recombinant protein of human GCK
Isotype
IgG
Top Product
Discover our top product GCK Primary Antibody
Alternatives
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Application Details
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Application Notes
WB 1:500-1:2000, IHC 1:50-1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.3 mg/mL
Buffer
PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
Preservative
Sodium azide
Handling Advice
Avoid freeze / thaw cycles.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for GCK
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Target
GCK
(Glucokinase (Hexokinase 4) (GCK))
Alternative Name
GCK (GCK Products )
Synonyms
FGQTL3 antibody, GK antibody, GLK antibody, HHF3 antibody, HK4 antibody, HKIV antibody, HXKP antibody, LGLK antibody, MODY2 antibody, Gk antibody, Gls006 antibody, GCK antibody, BA4487 antibody, glk antibody, hk4 antibody, hhf3 antibody, hkiv antibody, hxkp antibody, gck-A antibody, mody2 antibody, glucokinase antibody, GLUKA antibody, RNGK2 antibody, glucokinase antibody, glucokinase (hexokinase 4) L homeolog antibody, glucokinase (hexokinase 4) antibody, GCK antibody, Gck antibody, glcK antibody, Bphyt_1025 antibody, Halhy_6548 antibody, gk antibody, gck.L antibody, gck antibody
Background
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Molecular Weight
Calculated MW: 52 kDa
Pathways
MAPK Signaling , Positive Regulation of Peptide Hormone Secretion , Carbohydrate Homeostasis , Cellular Glucan Metabolic Process , Regulation of Carbohydrate Metabolic Process
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