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IL7R antibody (pTyr449)

IL7R Reactivity: Mouse WB, ELISA, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN233847
  • Target See all IL7R Antibodies
    IL7R (Interleukin 7 Receptor (IL7R))
    Binding Specificity
    • 22
    • 16
    • 9
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr449
    Reactivity
    • 110
    • 49
    • 26
    • 7
    • 4
    • 2
    • 1
    Mouse
    Host
    • 80
    • 36
    • 28
    • 1
    • 1
    Rabbit
    Clonality
    • 80
    • 64
    • 2
    Polyclonal
    Conjugate
    • 63
    • 11
    • 10
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL7R antibody is un-conjugated
    Application
    • 86
    • 76
    • 45
    • 26
    • 26
    • 12
    • 10
    • 8
    • 7
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP)
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus)
    Characteristics
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to residues near Y449 of mouse IL-7 protein.
    Isotype
    IgG
    Top Product
    Discover our top product IL7R Primary Antibody
  • Application Notes
    This affinity purified antibody has been tested for use in ELISA, immunoprecipitation, and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 55 kDa in size corresponding to phosphorylated IL-7 by western blotting in the appropriate cell lysate or extract.  This phospho-specific polyclonal antibody reacts with mouse IL-7 pY449 and shows minimal reactivity by ELISA against the non-phosphorylated form of the immunizing peptide.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.82 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Osborne, Dhanji, Snow, Priatel, Ma, Miners, Teh, Goldsmith, Abraham: "Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice." in: The Journal of experimental medicine, Vol. 204, Issue 3, pp. 619-31, (2007) (PubMed).

  • Target
    IL7R (Interleukin 7 Receptor (IL7R))
    Alternative Name
    IL-7 Receptor Alpha Chain (IL7R Products)
    Synonyms
    IL7R antibody, CD127 antibody, IL-7Ralpha antibody, CDW127 antibody, IL-7R-alpha antibody, IL7RA antibody, ILRA antibody, IL-7RA antibody, interleukin 7 receptor antibody, IL7R antibody, Il7r antibody
    Background
    This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Interleukin-7 is a glycoprotein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules.  The human and mouse sequence is nearly identical.  In humans, severe combined immunodeficiency is caused by genetic defects in IL-7 receptor. The tyrosine residue at the 449 position is a critical signaling site of the intracellular domain of IL-7 receptor. This site is rapidly phosphorylated by janus kinases after the IL-7 receptor is engaged. IL-7 Receptor Alpha Chain phospho Y449 Antibody is ideal for investigators involved in Cell Signaling, Signal Transduction and Immunology research.
    Synonyms: IL7Ralpha antibody, Interleukin 7 receptor alpha chain antibody, Interleukin 7 receptor antibody
    Gene ID
    16197, 45269152
    UniProt
    P16872
    Pathways
    JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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