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Selenoprotein W antibody

SEPW1 Reactivity: Mouse WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN233833
  • Target See all Selenoprotein W (SEPW1) Antibodies
    Selenoprotein W (SEPW1) (Selenoprotein W, 1 (SEPW1))
    Reactivity
    • 15
    • 13
    • 1
    Mouse
    Host
    • 29
    Rabbit
    Clonality
    • 29
    Polyclonal
    Conjugate
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Selenoprotein W antibody is un-conjugated
    Application
    • 18
    • 13
    • 13
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Specificity
    This product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody is specific for mouse Selenoprotein W.  A BLAST analysis was used to suggest cross-reactivity with SelW from rat based on a 98% homology with the immunizing sequence.  Partial reactivity is expected against human-derived SelW based on an 87% homology with the immunogen.  Cross-reactivity with SelW from other sources has not been determined.
    Characteristics
    This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Selenoprotein W was first purified and characterized from rat skeletal muscle. The function of selenoprotein W is not entirely clear, but the presence of the bound glutathione moiety indicates that SelW is thought to function in oxidation-reduction catalysis and may play a role in selenium deficiency disorders such as white muscle disease in sheep and Keshan disease in humans. Recently, overexpression of SelW was shown to be glutathione dependent and was shown to markedly reduce the sensitivity of cell lines to H2O2 cytotoxicity.
    Purification
    affinity purified
    Sterility
    Sterile filtered
    Immunogen
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to full-length mouse SelW protein.
    Immunogen Type: RecombinantProtein
    Isotype
    IgG
  • Application Notes
    This affinity purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 9.6 kDa in size corresponding to SelW by western blotting in the appropriate cell lysate or extract.  This antibody is capable of detecting both overexpressed and endogenous SelW.
    Comment

    Gene Name: SEPW1

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.38 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.
    Expiry Date
    3 months
  • Target
    Selenoprotein W (SEPW1) (Selenoprotein W, 1 (SEPW1))
    Alternative Name
    Selenoprotein W (SEPW1 Products)
    Synonyms
    SEPW1 antibody, sepw1 antibody, selw1 antibody, SelW antibody, selW antibody, SEPW antibody, cb694 antibody, fe37b06 antibody, wu:fe37b06 antibody, wu:fk70h03 antibody, zgc:109781 antibody, selenoprotein W antibody, selenoprotein W, 1 antibody, SELENOW antibody, sepw1 antibody, Selenow antibody, SEPW1 antibody, selenow1 antibody
    Background
    This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Selenoprotein W was first purified and characterized from rat skeletal muscle.  The function of selenoprotein W is not entirely clear, but the presence of the bound glutathione moiety indicates that SelW is thought to function in oxidation–reduction catalysis and may play a role in selenium deficiency disorders such as white muscle disease in sheep and Keshan disease in humans. Recently, overexpression of SelW was shown to be glutathione dependent and was shown to markedly reduce the sensitivity of cell lines to H2O2 cytotoxicity.
    Synonyms: Selenoprotein W SelW
    Gene ID
    20364, 2384723
    UniProt
    P63300
    Pathways
    Cell RedoxHomeostasis
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