PPP1R13B antibody (Internal Region)

Catalog No. ABIN233830

Product Details anti-PPP1R13B Antibody

Target: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP1R13B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an sequence of human ASPP1.

Isotype: IgG

Application Details

Application Notes: This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 120 kDa in size corresponding to ASPP1 by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for PPP1R13B

Target: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Alternative Name: ASPP1 (PPP1R13B Products)

Synonyms: ASPP1 antibody, p53BP2-like antibody, p85 antibody, AI449786 antibody, AW545810 antibody, Tp53bp2 antibody, Trp53bp2 antibody, protein phosphatase 1 regulatory subunit 13B antibody, protein phosphatase 1, regulatory subunit 13B antibody, protein phosphatase 1 regulatory subunit 13B L homeolog antibody, protein phosphatase 1, regulatory subunit 13Bb antibody, protein phosphatase 1, regulatory (inhibitor) subunit 13B antibody, PPP1R13B antibody, Ppp1r13b antibody, ppp1r13b.L antibody, ppp1r13bb antibody, ppp1r13b antibody

Background: ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.  ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.  In contrast, iASPP functionally inactivates p53.  ASPPs may also regulate p63- and p73-mediated apoptosis.  Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3.  Not all cell cycle arrest genes are affected, such as p21.  Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53.  Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.
Synonyms: p53BP2 like antibody, p85 antibody, PPP1R13B antibody

Gene ID: 23368, 121114287

UniProt: Q62415

Pathways: p53 Signaling