PLVAP antibody

Catalog No. ABIN2192062

Product Details anti-PLVAP Antibody

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PLVAP antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Sterility: 0.2 μm filtered

Clone: 174-2

Application Details

Application Notes: For immunohistology, flow cytometry, immunofluorescence and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Handling

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Expiry Date: 12 months

References for anti-PLVAP antibody (ABIN2192062)

Niemelä, Elima, Henttinen, Irjala, Salmi, Jalkanen: "Molecular identification of PAL-E, a widely used endothelial-cell marker." in: Blood, Vol. 106, Issue 10, pp. 3405-9, (2005) (PubMed).

Carson-Walter, Hampton, Shue, Geynisman, Pillai, Sathanoori, Madden, Hamilton, Walter: "Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 21, pp. 7643-50, (2005) (PubMed).

Target Details for PLVAP

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Alternative Name: Plasmalemma Vesicle Associated Protein (PLVAP Products)

Synonyms: MECA32 antibody, Pv1 antibody, FELS antibody, PV-1 antibody, PV1 antibody, gp68 antibody, plasmalemma vesicle associated protein antibody, Plvap antibody, PLVAP antibody

Background: The monoclonal antibody 174/2 reacts with human plasmalemma vesicle associated protein (PLVAP), also known as PV1, PAL-E and FELS. PLVAP is a 60 kDa type II transmembrane glycoprotein which tends to form homodimers. PLVAP is widely expressed in the vasculature of normal tissues. The vascular staining pattern of PLVAP is quite unique among the endothelial cell antigens, since expression of other antigens (like ICAM-1, P-selectin, E-selectin or VCAM-1) is not limited to vascular endothelial cells. PLVAP expression in the vascular endothelial cells of the CNS is lost in association with formation of an intact blood-brain barrier. However, in the endothelium of human brain tumors expression of PLVAP is specifically up-regulated, making it a suitable antiangiogenic target for brain tumor therapy and cerebral edema. Furthermore, PLVAP is expressed in the vasculature of most other human tumors and as such useful as marker for tumor angiogenesis.