CXCL10 antibody

Catalog No. ABIN2191895

Product Details anti-CXCL10 Antibody

Target: CXCL10 (Chemokine (C-X-C Motif) Ligand 10 (CXCL10))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CXCL10 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)

Sterility: 0.2 μm filtered

Clone: 6D4

Application Details

Application Notes: For immunohistochemistry, flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Positive Acitvated plasmacytoid dendritic cells control Negative Normal liver control 1

Restrictions: For Research Use only

Handling

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

References for anti-CXCL10 antibody (ABIN2191895)

Curbishley, Eksteen, Gladue, Lalor, Adams: "CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow." in: The American journal of pathology, Vol. 167, Issue 3, pp. 887-99, (2005) (PubMed).

Giustizieri, Albanesi, Scarponi, De Pità, Girolomoni: "Nitric oxide donors suppress chemokine production by keratinocytes in vitro and in vivo." in: The American journal of pathology, Vol. 161, Issue 4, pp. 1409-18, (2002) (PubMed).

Hamamdzic, Phillips-Dorsett, Altman-Hamamdzic, London, London: "Reovirus triggers cell type-specific proinflammatory responses dependent on the autocrine action of IFN-beta." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 280, Issue 1, pp. L18-29, (2001) (PubMed).

Target Details for CXCL10

Target: CXCL10 (Chemokine (C-X-C Motif) Ligand 10 (CXCL10))

Alternative Name: C-X-C Motif Chemokine 10 (CXCL10 Products)

Synonyms: CXCL10 antibody, C7 antibody, IFI10 antibody, INP10 antibody, IP-10 antibody, SCYB10 antibody, crg-2 antibody, gIP-10 antibody, mob-1 antibody, CRG-2 antibody, IP10 antibody, Ifi10 antibody, Scyb10 antibody, C-X-C motif chemokine ligand 10 antibody, C-X-C motif chemokine 10 antibody, chemokine (C-X-C motif) ligand 10 antibody, CXCL10 antibody, cxl10 antibody, Cxcl10 antibody

Background: The monoclonal antibody 6D4 recognizes human C-X-C motif chemokine 10 (IP-10), a protein of 98 amino acids. IP-10, also known as CXCL10, functions as ligand for the CXCR3 receptor. IP-10 belongs to the α-chemokine (C-X-C) family, which can be divided in two subfamilies: (1) potent chemoattractants for neutrophils, like IL-8 and (2) potent chemoattractants for lymphocytes, like the IFNγ inducible protein (IP)-10. IP-10 is produced by a wide variety of cell types ranging from neutrophils, dendritic cells and monocytes to hepatocytes, endothelial cells and keratinocytes. The cytokine is reported to be involved in a scala of inflammatory pathologies such as HIV, encephalitis, cutaneous T cell lymphoma, chronic hepatitis, psoriasis and acute anterior uveitis. Various observations strongly suggest a role for the C-X-C chemokines IL-8 and IP-10 in the regulation of angiogenic activity in cancer and in idiopathic pulmonary fibrosis. Furthermore IP-10 is associated with acute rejection processes estimated by the predictive properties of urinary IP-10 expression for the short- and long-term graft function after kidney transplantation. Aliases 10 kDa interferon gamma-induced protein, CXCL10, Small-inducible cytokine B10 Immunogen Recombinant human IP-10